The Review of Diabetic Studies
Vol. 9, Issue 4-Winter 2012
Quarterly
ISSN print edition 1613-6071
ISSN online edition 1614-0575

Content of No. 4 - 2012

Chapter I. Pathogenesis

Genetic Analysis of Type 1 Diabetes: Embryonic Stem Cells as New Tools to Unlock Biological Mechanisms in Type 1 Diabetes

Nick Holmes, Anne Cooke

Abstract
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Pathogenic Mechanisms in Type 1 Diabetes: The Islet is Both Target and Driver of Disease

Kate L. Graham, Robyn M. Sutherland, Stuart I. Mannering, Yuxing Zhao, Jonathan Chee, Balasubramanian Krishnamurthy, Helen E. Thomas, Andrew M. Lew, Thomas W.H. Kay

Abstract
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Comparative Genetics: Synergizing Human and NOD Mouse Studies for Identifying Genetic Causation of Type 1 Diabetes

John P. Driver, Yi-Guang Chen, Clayton E. Mathews

Abstract
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Protein Tyrosine Phosphatases and Type 1 Diabetes: Genetic and Functional Implications of PTPN2 and PTPN22

Karen Cerosaletti, Jane H. Buckner

Abstract
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From Markers to Molecular Mechanisms: Type 1 Diabetes in the Post-GWAS Era

Alan G. Baxter, Margaret A. Jordan

Abstract
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Novel Biomarkers in Type 1 Diabetes

Yulan Jin, Jin-Xiong She

Abstract
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Metabolomics in the Studies of Islet Autoimmunity and Type 1 Diabetes

Matej Oresic

Abstract
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Chapter II. Prevention

Gut Microbiota and Type 1 Diabetes

Outi Vaarala

Abstract
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Virus Infections as Potential Targets of Preventive Treatments for Type 1 Diabetes

Noora Nurminen, Sami Oikarinen, Heikki Hyƶty

Abstract
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Helminth Infection and Type 1 Diabetes

Paola Zaccone, Samuel W. Hall

Abstract
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Chapter III. Re-establishing Tolerance

Type 1 Diabetes Therapy Beyond T Cell Targeting: Monocytes, B Cells, and Innate Lymphocytes

F. Susan Wong, Li Wen

Abstract
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Targeted Antigen Delivery to DEC-205+ Dendritic Cells for Tolerogenic Vaccination

Cathleen Petzold, Sonja Schallenberg, Joel N.H. Stern, Karsten Kretschmer

Abstract
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Tolerance Strategies Employing Antigen-Coupled Apoptotic Cells and Carboxylated PLG Nanoparticles for the Treatment of Type 1 Diabetes

Suchitra Prasad, Dan Xu, Stephen D. Miller

Abstract
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Clinical Potential of Antigen-Specific Therapies in Type 1 Diabetes

Ken T. Coppieters, Birgit Sehested Hansen, Matthias G. von Herrath

Abstract
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Interleukin-1 Antagonists and Other Cytokine Blockade Strategies for Type 1 Diabetes

Thomas Mandrup-Poulsen

Abstract
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In Vivo Delivery of Nucleic Acid-Formulated Microparticles as a Potential Tolerogenic Vaccine for Type 1 Diabetes

Valentina Di Caro, Nick Giannoukakis, Massimo Trucco

Abstract
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Chapter IV. Clinical Trials

Immune-Directed Therapy for Type 1 Diabetes at the Clinical Level: The Immune Tolerance Network (ITN) Experience

Mario R. Ehlers, Gerald T. Nepom

Abstract
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CD3 Monoclonal Antibodies: A First Step Towards Operational Immune Tolerance in the Clinic

Lucienne Chatenoud, Herman Waldmann

Abstract
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Chapter V. Beta-Cell Replacement

Islet Transplantation in Type 1 Diabetes: Ongoing Challenges, Refined Procedures, and Long-Term Outcome

A.M. James Shapiro

Abstract
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Islet Neogenesis: A Possible Pathway for Beta-Cell Replenishment

Susan Bonner-Weir, Lili Guo, Wan-Chun Li, Limor Ouziel-Yahalom, Philippe A. Lysy, Gordon C. Weir, Arun Sharma

Abstract
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