The Review of Diabetic Studies
Vol.9, Issue 4-Winter 2012
ISSN print edition 1613-6071
ISSN online edition 1614-0575

Content of No. 4 - 2012

Chapter I. Pathogenesis

Genetic Analysis of Type 1 Diabetes: Embryonic Stem Cells as New Tools to Unlock Biological Mechanisms in Type 1 Diabetes

Nick Holmes, Anne Cooke

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Pathogenic Mechanisms in Type 1 Diabetes: The Islet is Both Target and Driver of Disease

Kate L. Graham, Robyn M. Sutherland, Stuart I. Mannering, Yuxing Zhao, Jonathan Chee, Balasubramanian Krishnamurthy, Helen E. Thomas, Andrew M. Lew, Thomas W.H. Kay

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Comparative Genetics: Synergizing Human and NOD Mouse Studies for Identifying Genetic Causation of Type 1 Diabetes

John P. Driver, Yi-Guang Chen, Clayton E. Mathews

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Protein Tyrosine Phosphatases and Type 1 Diabetes: Genetic and Functional Implications of PTPN2 and PTPN22

Karen Cerosaletti, Jane H. Buckner

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From Markers to Molecular Mechanisms: Type 1 Diabetes in the Post-GWAS Era

Alan G. Baxter, Margaret A. Jordan

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Novel Biomarkers in Type 1 Diabetes

Yulan Jin, Jin-Xiong She

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Metabolomics in the Studies of Islet Autoimmunity and Type 1 Diabetes

Matej Oresic

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Chapter II. Prevention

Gut Microbiota and Type 1 Diabetes

Outi Vaarala

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Virus Infections as Potential Targets of Preventive Treatments for Type 1 Diabetes

Noora Nurminen, Sami Oikarinen, Heikki Hyƶty

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Helminth Infection and Type 1 Diabetes

Paola Zaccone, Samuel W. Hall

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Chapter III. Re-establishing Tolerance

Type 1 Diabetes Therapy Beyond T Cell Targeting: Monocytes, B Cells, and Innate Lymphocytes

F. Susan Wong, Li Wen

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Targeted Antigen Delivery to DEC-205+ Dendritic Cells for Tolerogenic Vaccination

Cathleen Petzold, Sonja Schallenberg, Joel N.H. Stern, Karsten Kretschmer

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Tolerance Strategies Employing Antigen-Coupled Apoptotic Cells and Carboxylated PLG Nanoparticles for the Treatment of Type 1 Diabetes

Suchitra Prasad, Dan Xu, Stephen D. Miller

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Clinical Potential of Antigen-Specific Therapies in Type 1 Diabetes

Ken T. Coppieters, Birgit Sehested Hansen, Matthias G. von Herrath

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Interleukin-1 Antagonists and Other Cytokine Blockade Strategies for Type 1 Diabetes

Thomas Mandrup-Poulsen

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In Vivo Delivery of Nucleic Acid-Formulated Microparticles as a Potential Tolerogenic Vaccine for Type 1 Diabetes

Valentina Di Caro, Nick Giannoukakis, Massimo Trucco

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Chapter IV. Clinical Trials

Immune-Directed Therapy for Type 1 Diabetes at the Clinical Level: The Immune Tolerance Network (ITN) Experience

Mario R. Ehlers, Gerald T. Nepom

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CD3 Monoclonal Antibodies: A First Step Towards Operational Immune Tolerance in the Clinic

Lucienne Chatenoud, Herman Waldmann

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Chapter V. Beta-Cell Replacement

Islet Transplantation in Type 1 Diabetes: Ongoing Challenges, Refined Procedures, and Long-Term Outcome

A.M. James Shapiro

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Islet Neogenesis: A Possible Pathway for Beta-Cell Replenishment

Susan Bonner-Weir, Lili Guo, Wan-Chun Li, Limor Ouziel-Yahalom, Philippe A. Lysy, Gordon C. Weir, Arun Sharma

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