The Review of Diabetic Studies
Vol.9, Issue 4-Winter 2012
Quarterly
ISSN print edition 1613-6071
ISSN online edition 1614-0575

Content of No. 4 - 2012

Chapter I. Pathogenesis

Genetic Analysis of Type 1 Diabetes: Embryonic Stem Cells as New Tools to Unlock Biological Mechanisms in Type 1 Diabetes

NickHolmes, AnneCooke

Abstract
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Pathogenic Mechanisms in Type 1 Diabetes: The Islet is Both Target and Driver of Disease

Kate L.Graham, Robyn M.Sutherland, Stuart I.Mannering, YuxingZhao, JonathanChee, BalasubramanianKrishnamurthy, Helen E.Thomas, Andrew M.Lew, Thomas W.H.Kay

Abstract
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Comparative Genetics: Synergizing Human and NOD Mouse Studies for Identifying Genetic Causation of Type 1 Diabetes

John P.Driver, Yi-GuangChen, Clayton E.Mathews

Abstract
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Protein Tyrosine Phosphatases and Type 1 Diabetes: Genetic and Functional Implications of PTPN2 and PTPN22

KarenCerosaletti, Jane H.Buckner

Abstract
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From Markers to Molecular Mechanisms: Type 1 Diabetes in the Post-GWAS Era

Alan G.Baxter, Margaret A.Jordan

Abstract
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Novel Biomarkers in Type 1 Diabetes

YulanJin, Jin-XiongShe

Abstract
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Metabolomics in the Studies of Islet Autoimmunity and Type 1 Diabetes

MatejOresic

Abstract
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Chapter II. Prevention

Gut Microbiota and Type 1 Diabetes

OutiVaarala

Abstract
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Virus Infections as Potential Targets of Preventive Treatments for Type 1 Diabetes

NooraNurminen, SamiOikarinen, HeikkiHyƶty

Abstract
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Helminth Infection and Type 1 Diabetes

PaolaZaccone, Samuel W.Hall

Abstract
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Chapter III. Re-establishing Tolerance

Type 1 Diabetes Therapy Beyond T Cell Targeting: Monocytes, B Cells, and Innate Lymphocytes

F. SusanWong, LiWen

Abstract
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Targeted Antigen Delivery to DEC-205+ Dendritic Cells for Tolerogenic Vaccination

CathleenPetzold, SonjaSchallenberg, Joel N.H.Stern, KarstenKretschmer

Abstract
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Tolerance Strategies Employing Antigen-Coupled Apoptotic Cells and Carboxylated PLG Nanoparticles for the Treatment of Type 1 Diabetes

SuchitraPrasad, DanXu, Stephen D.Miller

Abstract
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Clinical Potential of Antigen-Specific Therapies in Type 1 Diabetes

Ken T.Coppieters, BirgitSehested Hansen, Matthias G.von Herrath

Abstract
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Interleukin-1 Antagonists and Other Cytokine Blockade Strategies for Type 1 Diabetes

ThomasMandrup-Poulsen

Abstract
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In Vivo Delivery of Nucleic Acid-Formulated Microparticles as a Potential Tolerogenic Vaccine for Type 1 Diabetes

ValentinaDi Caro, NickGiannoukakis, MassimoTrucco

Abstract
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Chapter IV. Clinical Trials

Immune-Directed Therapy for Type 1 Diabetes at the Clinical Level: The Immune Tolerance Network (ITN) Experience

Mario R.Ehlers, Gerald T.Nepom

Abstract
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CD3 Monoclonal Antibodies: A First Step Towards Operational Immune Tolerance in the Clinic

LucienneChatenoud, HermanWaldmann

Abstract
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Chapter V. Beta-Cell Replacement

Islet Transplantation in Type 1 Diabetes: Ongoing Challenges, Refined Procedures, and Long-Term Outcome

A.M. JamesShapiro

Abstract
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Islet Neogenesis: A Possible Pathway for Beta-Cell Replenishment

SusanBonner-Weir, LiliGuo, Wan-ChunLi, LimorOuziel-Yahalom, Philippe A.Lysy, Gordon C.Weir, ArunSharma

Abstract
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