Section
|
Topic
|
Authors
|
I. Pathogenesis
|
New tools - NOD ES cells
|
Anne Cooke and Nick Holmes
|
|
Pathogenic mechanisms in type 1 diabetes
|
Thomas Kay
|
|
Genetics and function (mouse versus human)
|
Clayton E. Mathews
|
|
Phosphatase polymorphisms and type 1 diabetes (human PTPN22, PTPN2)
|
Jane Buckner
|
|
Post-GWAS era in type 1 diabetes: use of GWAS data to understand diabetes at the molecular level
|
Alan Baxter
|
|
Novel biomarkers in T1D
|
Yulan Jinand, Jin-Xiong She
|
|
New findings on autoantigens
|
Maki Nakayama
|
|
Metabolomics and islet autoimmunity
|
Matej Oresic
|
II. Prevention
|
Gut microbiota and type 1 diabetes
|
Outi Vaarala
|
|
Interaction of environmental factors and islet autoimmunity, viral infections
|
Heikki Hyöty
|
|
Infection-helminths and type 1 diabetes
|
Paola Zaccone
|
III. Re-establishing tolerance
|
Type 1 diabetes therapy beyond T cell targeting: monocytes, B cells, and innate lymphocytes
|
Susan Wong
|
|
Dendritic and B cell-based approaches (i.e. targeting antigens to tolerogenic Dcs)
|
Karsten Kretschmer
|
|
ECDI-fixed antigen-pulsed PBMCs (and other tolerance approaches in NOD mice and T1D and comparison/contrast to use of Ag-coupled cells and Ag-nanoparticles)
|
Stephen D. Miller
|
|
New efforts to bring antigen-specific therapies to the clinic (new NovoNordisk T1D R&D center)
|
Matthias von Herrath and Ken Coppieters
|
|
Antigen and DNA vaccination in type 1 diabetes
|
Len Harrison
|
|
IL1Ra antagonists and other cytokine blockade strategies
|
Thomas Mandrup-Poulsen
|
|
pMHC-coated nanoparticles
|
Pere Santamaria
|
|
Microparticle-based delivery of antisense or siRNA to local DCs
|
Massimo Trucco
|
IV. Where are we with clinical trials?
|
Immune-directed type 1 diabetes therapy in the clinic - The Immune Tolerance Network
|
Gerald T. Nepom and Mario Ehlers
|
|
Type 1 diabetes therapy in clinical testing: European trials with aCD3
|
Lucienne Chatenoud and Herman Waldmann
|
V. Beta-cell replacement
|
Islet transplantation in type 1 diabetes
|
AM James Shapiro
|
|
Neogenesis
|
Susan Bonner-Weir, et al.
|
