Tracing the Pathogenesis of Type 1 Diabetes: A Report on the 44th Annual Meeting of the European Association for the Study of Diabetes (EASD)

Conference Report

Rev Diabet Stud, 2008, 5(3):171-174

DOI 10.1900/RDS.2008.5.171

Tracing the Pathogenesis of Type 1 Diabetes: A Report on the 44th Annual Meeting of the European Association for the Study of Diabetes (EASD)

Liang-Hao Guo, Peter Achenbach

Diabetes Research Institute, Munich, Germany
Address correspondence to: Peter Achenbach, e-mail: peter.achenbach@lrz.uni-muenchen.de

Manuscript submitted November 2, 2008; resubmitted November 4, 2008; accepted November 6, 2008.

Keywords: type 1 diabetes, prediction, biomarker, autoantibody, zinc transporter, ZnT8, SLC30A8, metabolism, insulin resistance

Abstract

Clinical type 1 diabetes is preceded by autoimmune destruction of the pancreatic beta-cells. However, progression to disease is not uniform. One challenge facing current diabetes research is therefore to identify biomarker profiles that accurately reflect the individual stage of type 1 diabetes pathogenesis and develop new techniques to distinguish between these profiles and associated diabetes risks. This report highlights some of the recent studies on diabetes biomarkers, with a particular focus on zinc transporter ZnT8, presented at the EASD meeting in September 2008 in Rome, Italy.

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