Causes and Characteristics of Diabetic Cardiomyopathy

Review

Rev Diabet Stud, 2006, 3(3):108-117

DOI 10.1900/RDS.2006.3.108

Causes and Characteristics of Diabetic Cardiomyopathy

Jianxun Wang¹, Ye Song², Qianwen Wang³, Patricia M. Kralik², Paul N. Epstein²

¹Departments of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40202, USA.
²Department of Pediatrics, University of Louisville, Louisville, KY 40202, USA.
³Department of Physiology and Biophysics, University of Louisville, Louisville, KY 40202, USA.
Address correspondence to: Paul N. Epstein, e-mail: paul.epstein@louisville.edu

Keywords: diabetes, cardiomyopathy, coronary artery disease, obesity, hyperglycemia, insulin, angiotensin

Abstract

Type 1 and type 2 diabetic patients are at increased risk of cardiomyopathy and heart failure is a major cause of death for these patients. Cardiomyopathy in diabetes is associated with a cluster of features including decreased diastolic compliance, interstitial fibrosis and myocyte hypertrophy. The mechanisms leading to diabetic cardiomyopathy remain uncertain. Diabetes is associated with most known risk factors for cardiac failure seen in the overall population, including obesity, dyslipidemia, thrombosis, infarction, hypertension, activation of multiple hormone and cytokine systems, autonomic neuropathy, endothelial dysfunction and coronary artery disease. In light of these common contributing pathologies it remains uncertain whether diabetic cardiomyopathy is a distinct disease. It is also uncertain which factors are most important to the overall incidence of heart failure in diabetic patients. This review focuses on factors that can have direct effects on diabetic cardiomyocytes: hyperglycemia, altered fuel use, and changes in the activity of insulin and angiotensin. Particular attention is given to the changes these factors can have on cardiac mitochondria and the role of reactive oxygen species in mediating injury to cardiomyocytes.

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