Original Data

Rev Diabet Stud, 2007, 4(4):236-241 DOI 10.1900/RDS.2007.4.236

First-Degree Relatives of Patients with Type 2 Diabetes Mellitus and Risk of Non-Alcoholic Fatty Liver Disease

Atoosa Adibi1, Mohsen Janghorbani2,3, Sanaz Shayganfar1, Masoud Amini3

1Department of Radiology, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran
2Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran
3Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Address correspondence to: Mohsen Janghorbani, e-mail: janghorbani @ yahoo.com

Manuscript submitted November 21, 2007; resubmitted January 29, 2008; accepted February 19, 2008.

Keywords: type 2 diabetes, non-alcoholic fatty liver, obesity, first-degree relatives of T2DM patients, risk factors, ultrasonography


AIMS: The aim of this study was to determine whether first-degree relatives (FDR) of patients with type 2 diabetes mellitus (T2DM) are at higher risk of non-alcoholic fatty liver disease (NAFLD) than healthy controls. METHODS: A total of 222 FDR of consecutive patients with T2DM aged between 35 and 55 years and 202 healthy individuals with no family history of diabetes were investigated for NAFLD. Fatty liver was diagnosed by ultrasonography using standard criteria. Height, weight, fasting glucose, alanine aminotransferase (ALT), total cholesterol and triglyceride were determined by routine laboratory methods. RESULTS: Compared to subjects with no family history of diabetes, the age and sex adjusted odds ratio (OR) of NAFLD was 1.83 (95% CI: 1.11-3.03) for FDR of patients with T2DM. After further adjusting for BMI, fasting glucose, ALT, asparate aminotransferase (AST), triglyceride and cholesterol, the multivariate OR of prevalent NAFLD in FDR of patients with T2DM compared with individuals with no family history of diabetes was 1.56 (95% CI: 0.85-2.86). CONCLUSIONS: The present study suggests that the relation between FDR of patients with T2DM and NAFLD is affected by the other covariates, in particular obesity, which points to a more complex relationship between the diseases. It appears that obesity and diabetes may independently predispose to NAFLD.

Fulltext: HTML , PDF (280KB)

This article has been cited by other articles:

First multicenter study for risk factors for hepatocellular carcinoma development in North Africa

Bahri O, Ezzikouri S, Alaya-Bouafif NB, Iguer F, Feydi AE, Mestiri H, Benazzouz M, Khalfallah T, Afifi R, Elkihal L, Berkane S, Marchio A, Debzi N, Dejean A, Pineau P, Triki H, Benjelloun S

World J Hepatol 2011. 3(1):24-30

Common SPINK-1 mutations do not predispose to the development of non-alcoholic fatty liver disease

Oruc N, Ozutemiz O, Akarca US, Berdeli A, Ersoz G, Gunsar F, Karasu Z, Ilter T, Batur Y

Ann Hepatol 2009. 8(2):116-119

Impact of type 2 diabetes mellitus on non-alcoholic fatty liver disease

Lin G, Zhong Y, Fan J

Int J Dig Dis 2008. 28(6):455-457